What is tmax

The time to peak concentration is of pragmatic importance because it varies between individuals and can be manipulated through the various routes of administration e. Thalidomide, for example, has an average Tmax of 4 h; however, the time to reach peak concentration can vary between 1 and 7 h Figg et al. Drugs with short half-lives tend to peak and eliminate quickly, often requiring more frequent dosing to maintain a drug within its clinically effective therapeutic range.

Skip to main content Skip to table of contents. This service is more advanced with JavaScript available. Encyclopedia of Clinical Neuropsychology Edition. C max is the maximum peak plasma drug concentration attained after the oral administration of the drug.

Also, at t max , the drug absorption rate exactly equals the drug elimination rate. The t max is dependent on the elimination rate k and absorption rate constant ka. At tmax, the concentration of a drug is in peak. It is Peak plasma time. It is elimination half-life. Certara Appoints James E. Contact Investors Careers Support. Mon, February 11th Knowledge Base. Contact Us. About the author. Teuscher has been involved in clinical pharmacology and pharmacometrics work since He holds a PhD in Pharmaceutical Sciences from the University of Michigan and has held leadership roles at biotechnology companies, contract research organizations, and mid-sized pharmaceutical companies.

Prior to joining Certara, Dr. At Certara, Dr. Teuscher developed the software training department, led the software development of Phoenix, and now works as a pharmacometrics consultant. He specializes in developing fit-for-purpose models to support drug development efforts at all stages of clinical development. He has worked in multiple therapeutic areas including immunology, oncology, metabolic disorders, neurology, pulmonary, and more.

This concentration measure per se is a measure of extreme drug exposure, not absorption rate. This paper redirects attention to Tmax as the absorption rate variable.